A study to characterize the humoral and cellular response following simultaneous immunization with a neo-antigen (KLH) and a recall antigen (tetanus) in healthy volunteers.

Condition: Healthy Volunteers
Sponsor: Centre for Human Drug Research (Netherlands) 
Phase 4

NCT02947854

Study to Assess Safety, Tolerability and Immune Response of Fimaporfin-induced Photochemical Internalisation of Antigen/Adjuvant

An Open-label, Phase I/Proof of Principle, Dose Escalation Study to Assess Safety, Tolerability and Immune Response of Fimaporfin-induced Photochemical Internalisation (PCI) of Antigen/Adjuvant in Healthy Male/Female Subjects

Condition: Healthy Volunteers
Sponsor: PCI Biotech
Phase 1 

NCT02800811

Safety, Tolerability, PK, PD, and Immunogenicity of Single and Multiple Ascending Intravenous Doses of FR104

First-in-human, phase I, randomized, double-blind, placebo-controlled, single center study evaluating single and multiple ascending intravenous doses of FR104 in healthy subjects.

Condition: Healthy Volunteers
Sponsor: OSE Immunotherapeutics
Phase 1 

Relates to J Immunol. 2016 Dec 15;197(12):4593-4602. Epub 2016 Nov 14.

NCT02079480

Study to Evaluate the Safety, Tolerability, PK, and PD of CD40 in Healthy Subjects (CD40 FIH)

Condition: n/a  (Healthy Adults)
Sponsor: Bristol-Myers Squibb
Phase I

Characterization of human peripheral and intestinal T-cell responses after mucosal antigen exposure: induction of tolerance vs. immunization by oral administration of KLH

Condition: n/a (Healthy Volunteers)
Sponsor: Charite University Berlin
Phase: n/a 

NCT01489956

A Study to Determine the Immunogenicity and Oral Tolerance to Keyhole Limpet Hemocyanin (KLH)

Conditions: Autoimmune Disorders
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID) 
Phase 0 completed

NCT01027780

Mindfulness to Improve Elders' Immune and Health Status

Conditions: Stress, Psychologic
Sponsors: Univeristy of Rochester, National Institute on Aging (NIA)
Phase n/a