NCT02576145

A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax)

Immune Response to Neoantigen and Recall Antigen in Pediatric Renal Transplant Recipients Treated With the IL-2R Alfa Monoclonal Antibody, Daclizumab (Zenapax®)

Sponsor: Hoffman-La Roche
Condition: Kidney Transplantation
Phase 4 

NCT02545868

A Study to Evaluate the Effects of Ocrelizumab on Immune Responses In Participants With Relapsing Forms of Multiple Sclerosis

This multicenter, randomized, open-label study will evaluate the immune response to vaccines (tetanus toxoid [TT], 23-valent pneumococcal polysaccharide vaccine [23-PPV], influenza vaccine, and keyhole limpet hemocyanin [KLH]) after administration of a dose of ocrelizumab (OCR) in participants with relapsing multiple sclerosis (RMS).

Condition: Multiple Sclerosis, Relapsing-Remitting

Sponsor: Hoffman-LaRoche
Phase 3 

NCT02543749

DC Vaccination in CML

Dendritic Cells as Autologous Vaccine in Patients With Chronic Myeloid Leukemia

Condition: Chronic Myeloid Leukemia
Sponsor: Charite University, Berlin, Germany
Phase 1
Phase 2  

NCT02508896

Study Assessing Safety, Immunogenicity and LDLc -Lowering Activity of 2 PCSK9 Targeting AFFITOPE Vaccines in Healthy Subjects (AFF012)

A Single-blind Phase 1 Study Assessing the Safety, Immunogenicity and Low Density Lipoprotein Cholesterol (LDLc)-Lowering Activity of 2 Different Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Targeting AFFITOPE® Vaccines in Healthy Subjects

Condition: Hypercholesterolemia
Sponsor: Affiris AG
Collaborator: Medical University of Vienna
Phase 1
 

NCT02455557

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

A Phase II Study of the Safety and Efficacy of SVN53-67/M57-KLH (SurVaxM) in Survivin-Positive Newly Diagnosed Glioblastoma

Condition: Glioblastoma
Sponsor: Roswell Park Cancer Institute
Collaborator: National Cancer Institute (NCI) 
Phase 2 

NCT02334735

A Comparison of Matured Dendritic Cells and Montanide® in Study Subjects With High Risk of Melanoma Recurrence

A Phase II Open Label, Randomized Study of Poly-ICLC Matured DC as an Adjuvant for NY-ESO-1 and Melan-A/MART-1 Peptide Vaccination Compared to Montanide® ISA-51 VG, in Study Subjects With Melanoma in Complete Clinical Remission But at High Risk of Disease Recurrence

Conditions: Melanoma
Sponsor: Nina Bhardwaj
Collaborators: New York University School of Medicine, Memorial Sloan-Kettering Cancer Center, Ludwig Institute for Cancer Research, Melanoma Research Alliance, Oncovir Inc.
Phase 2

NCT02334865

SVN53-67/M57-KLH Peptide Vaccine in Treating Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide Maintenance Therapy

A Phase I Study of Safety, Tolerability and Immunological Effects of SVN53-67/M57-KLH in Patients With Multiple Myeloma Receiving Lenalidomide Maintenance Therapy

Conditions: Multiple Myeloma or Plasma Cell Leukemia, Plasma Cell Myeloma
Sponsor: Roswell Park Cancer Institute
Collaborator: National Cancer Institute (NCI) 
Phase 1

NCT02334735

A Comparison of Matured Dendritic Cells and Montanide® in Study Subjects With High Risk of Melanoma Recurrence

A Phase II Open Label, Randomized Study of Poly-ICLC Matured DC as an Adjuvant for NY-ESO-1 and Melan-A/MART-1 Peptide Vaccination Compared to Montanide® ISA-51 VG, in Study Subjects With Melanoma in Complete Clinical Remission But at High Risk of Disease Recurrence

Condition: Melanoma
Sponsor: Nina Bhardwaj
Collaborators: New York Univ School of Medicine, MEmorial Sloan-Kettering Cancer Center, Ludwig Institute for Cancer Research, Melanoma Research Alliance, Oncovir, Inc. 

NCT02270489

Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA (AFF009)

A Randomized, Placebo-controlled, Parallel Group, Patient-blind, Phase I Study Assessing the Safety and Exploring the Immunogenicity/Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early Multiple System Atrophy

Conditions: Multiple System Atrophy, Neurodegenerative Diseases
Sponsor: Affiris AG
Collaborators: University Hospital, Bordeaux; Institut National de la Santé Et de la Recherche Médicale, France; Forschungszentrum Juelich; University Hospital, Toulouse
Phase 1 

 

NCT02267434

Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease (AFF011)

A Randomized, Placebo-controlled, Parallel Group, Patient-blinded, Multi-center, Phase I Pilot Study to Assess Tolerability and Safety of Two Doses of AFFITOPE® PD03A Formulated With Adjuvant to Patients With Early Parkinson's Disease

Condition:  Parkinson's Disease
Sponsor: AFFiRis
Collaborators:  PROSENEX Ambulatoriumbetriebs GMBH, Medical University Innsbruck, Forschungszentrum Juelich
Phase 1